Extracellular DNA release confers heterogeneity in Candida albicans biofilm formation
نویسندگان
چکیده
منابع مشابه
Characteristics of biofilm formation by Candida albicans.
A variety of manifestations of Candida albicans infections are associated with the formation of biofilms on the surface of biomaterials. Cells in biofilms display phenotypic traits that are dramatically different from their free-floating planktonic counterparts, such as increased resistance to anti-microbial agents and protection form host defenses. Here, we describe the characteristics of C. a...
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Biofilm formation is often considered to be the underlying reason why treatment with an antimicrobial agent fails and as an estimated 65-80% of all infections is thought to be biofilm-related, this presents a serious challenge. Considerable attention has been devoted to the development of modified materials that prevent (or at least drastically reduce) microbial biofilm formation. In this revie...
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Candida albicans biofilm formation is an important virulence factor in the pathogenesis of disease, a characteristic which has been shown to be heterogeneous in clinical isolates. Using an unbiased computational approach we investigated the central metabolic pathways driving biofilm heterogeneity. Transcripts from high (HBF) and low (LBF) biofilm forming isolates were analysed by RNA sequencing...
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Candida albicans has the ability to change between yeast and hyphal cells and is known to be a virulence property. Efg1gene of C.albicans is as a main transcription factor that plays pivotal roles in biofilm formation The aim of the current study is to investigate the presence of Efg1 gene in Candida albicans isolates from women with vaginal candidiasis and its impact on biofilm formation.We us...
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ژورنال
عنوان ژورنال: BMC Microbiology
سال: 2014
ISSN: 1471-2180
DOI: 10.1186/s12866-014-0303-6